Tadasu Nozaki (Former Graduate Student at NIG)and Prof. Kazuhiro Maeshima (NIG) et. al. together with Drs Soya Shinkai and Shuichi Onami have found euchromatin forms condensed chromatin domains. This finding suggests an innovative model that condensed structure is the default state of chromatin.
Learn more about the study on Press Release from the National Institute of Genetics.
Nozaki, T., Shinkai, S., Ide, S., Higashi, K., Tamura, S., Shimazoe, M. A., Nakagawa, M., Suzuki, Y., Okada, Y., Sasai, M., Onami, S., Kurokawa, K., Iida, S., Maeshima, K. (2023). Condensed but liquid-like domain organization of active chromatin regions in living human cells. Sci. Adv. 9, eadf1488.
Excited to share our new paper @ScienceAdvances:https://t.co/0LVVQy2dbF
Dual-color imaging of two neighbor nucleosomes reveals that nucleosomes in euchromatin form condensed domains with ~150 nm diameter. Nucleosomes locally fluctuate in the condensed domain like a liquid. 1/ pic.twitter.com/4SLE0YLeXG
— Kazuhiro Maeshima (@kazu_maeshima) April 5, 2023