New paper by Dr Soya Shinkai has been published.
Understanding how chromosomes move inside living cells requires quantitative models linking genome structure to chromatin dynamics. Here, using genome-wide live-cell imaging together with our PHi-C technology, a Hi-C data-constrained polymer modeling approach, we built an integrative, physics-based “digital twin” of the fission yeast genome that reproduces its spatiotemporal chromatin dynamics. The model captures known architectural features, reveals characteristic chromatin relaxation times, and shows that low-frequency forces generated outside the nucleus propagate through the spindle pole body and centromeres to drive genome-wide chromatin displacement. This work provides a physical framework for understanding how nuclear mechanics shapes genome dynamics and function.
Reference
S. Shinkai, T. Namba, T. Sugawara, S. Hagiwara, S. Onami, T. Haraguchi, Y. Hiraoka, A. Awazu, M. Ueno, & S. Tate, Integrative modeling of the genome structure and dynamics in fission yeast, Proc. Natl. Acad. Sci. U.S.A. 123 (37) e2612002123, (2026). doi: 10.1073/pnas.2612002123